The Marlborough Center Historic District is a historic district encompassing the civic and commercial heart of Marlborough, Massachusetts. It is centered on a stretch of Main Street between Mechanic Street to the west and Bolton Street to the east, and includes properties on adjacent streets. The center is reflective of the city's prosperity as an industrial center from the mid-19th century to the mid-20th century. The district was listed on the National Register of Historic Places in 1998.